1D5R: Crystal Structure of the PTEN Tumor Suppressor - RCSB PDB
1999年10月11日 · The PTEN structure reveals a phosphatase domain that is similar to protein phosphatases but has an enlarged active site important for the accommodation of the phosphoinositide substrate. The structure also reveals that PTEN has a C2 domain.
PTEN (gene) - Wikipedia
The two domains of PTEN, a protein tyrosine phosphatase domain and a C2 domain, are inherited together as a single unit and thus constitute a superdomain, not only in PTEN but also in various other proteins in fungi, plants and animals, for example, tensin proteins and auxilin.
Crystal Structure of the PTEN Tumor Suppressor - Cell Press
1999年10月29日 · The PTEN structure reveals a phosphatase domain that is similar to protein phosphatases but has an enlarged active site important for the accommodation of the phosphoinositide substrate. The structure also reveals that PTEN has a C2 domain.
The structural basis of PTEN regulation by multi-site ... - Nature
2021年10月8日 · To further assess the functional significance of the PTEN/VSP N-terminal segment in the PTEN phospho-C-tail interaction, we generated a series of VSP and PTEN mutant proteins.
The functions and regulation of the PTEN tumour suppressor
2012年4月4日 · It has been well documented that a pool of PTEN proteins is localized to, and is functional within, the nucleus.
Crystal structure of the PTEN tumor suppressor: implications for …
1999年10月29日 · The PTEN structure reveals a phosphatase domain that is similar to protein phosphatases but has an enlarged active site important for the accommodation of the phosphoinositide substrate. The structure also reveals that PTEN has a C2 domain.
The Structural Basis of PTEN Regulation by Multi-Site …
Although this structure has informed on PTEN biology over the past 20 years, a detailed portrait of the N-terminal segment and C-terminal tail has remained elusive. In addition to mutation, PTEN function is silenced epigenetically as well as by post-translational modifications (PTMs).
PTEN was initially identified as a protein tyrosine phos - phatase (PTP) on the basis of its sequence homology in the catalytic domain to members of the PTP family 1–3 .
PTEN function: how normal cells control it and tumour cells lose it
Here we discuss recent developments in our understanding of how the cellular activity of PTEN is regulated, and the closely related question of how this activity is lost in tumours.
PTEN protein structure. PTEN is composed of 403-amino acids …
PTEN is a tumor suppressor gene located at chromosome 10q23.31, encoding for a 403-amino acid protein that possesses both lipid and protein phosphatase activities.
跳至内容