Phosphatidylinositol - Wikipedia
Phosphatidylinositol (PI), also known as inositol phospholipid, is a lipid composed of a phosphate group, two fatty acid chains, and one inositol molecule. It belongs to the class of …
Phosphoinositides as membrane organizers - Nature
2022年5月19日 · Here we review our current understanding of how phosphoinositides shape and direct membrane dynamics to impact on cell physiology, and provide an overview of emerging …
Understanding phosphoinositides: rare, dynamic, and essential …
PPIs ( polyphosphoinositides) are reversibly phosphorylated derivatives of the membrane phospholipid phosphatidylinositol (PI, Figure 1A). They are low-abundance lipids of the …
Phosphoinositides: lipid regulators of membrane proteins - PMC
Phosphoinositides are a family of minority acidic phospholipids in cell membranes. Their principal role is instructional: they interact with proteins. Each cellular membrane compartment uses a …
Phosphoinositides: multipurpose cellular lipids with emerging …
2019年2月11日 · Phosphorylated phosphatidylinositol lipids, or phosphoinositides, critically regulate diverse cellular processes, including signalling transduction, cytoskeletal …
Phosphoinositides: Regulators of Nervous System Function in …
Phosphoinositides, the seven phosphorylated derivatives of phosphatidylinositol have emerged as regulators of key sub-cellular processes such as membrane transport, cytoskeletal function …
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
The two main routes of PPI elimination are through dephosphorylation by PPI phosphatases and hydrolysis by phosphoinositide-specific phospholipase C enzymes (PLCs).
Phosphoinositides in cell regulation and membrane dynamics
2006年10月12日 · Phosphoinositides achieve direct signalling effects through the binding of their head groups to cytosolic proteins or cytosolic domains of membrane proteins. Thus, they can …
Great Expectations for PIP: Phosphoinositides as ... - Cell Press
2009年1月20日 · A second, very well-studied phosphoinositide signaling pathway results from the activation of PI 3-kinases (PI3Ks). Downstream of stimulation by growth factors, hormones, or …
Phosphoinositide switches in cell physiology - From molecular ...
Phosphoinositides (PIPs) are phosphorylated derivatives of phosphatidylinositol (PI), a ubiquitous phospholipid in the cytoplasmic leaflet of eukaryotic membranes that serves a plethora of …