In vitro differentiation modifies the neurotoxic response of SH-SY5Y cells
The SH-SY5Y cell line is commonly used for the assessment of neurotoxicity in drug discovery. These neuroblastoma-derived cells can be differentiated into neurons using many methods. The present study has compared 24 of these differentiation methods on SH-SY5Y cells.
Cell toxicity study on SH-SY5Y cell line at five different doses.
The evaluation of the neuroprotection effect of compound SD-30 (10,20,40, and 50 mM) on human neuroblastoma SH-SY5Y cell lines was assessed through MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl...
Cell toxicity (a) and viability (b) in treated and control SH-SY5Y ...
Here, we show that rutin prevents lysosomal dysfunction and aminochrome-induced cell death in SHSY-5Y cells, protects PCMC against aminochrome cytotoxicity, and prevents in vivo loss of...
Cellular Toxicity of Mesoporous Silica Nanoparticle in SHSY5Y …
The in vitro toxicity of MSN in bone marrow mononuclear cells and SHSY5Y cell was investigated in a time and dose-dependent manner. These results also confirmed no significant toxic effect at a low dose while at the higher doses, toxicity was observed.
Wnt3a protects SH-SY5Y cells against 6-hydroxydopamine toxicity …
Wnt3a-conditioned medium (Wnt3a-CM) was used to intervene dopaminegic SH-SY5Y cells treated with 6-OHDA. Cell toxicity was determined by cell viability and lactate dehydrogenase leakage (LDH) assay.
Cell viability (A) and toxicity (B) in treated and untreated SH-SY5Y...
In rotenone-treated SH-SY5Y cells, 10 µM rutin hydrate prevented apoptosis by inhibiting Bax translocation, inhibiting JNK, and increasing Bcl-2 protein levels .
The SH-SY5Y human neuroblastoma cell line, a relevant in vitro cell ...
2022年9月1日 · In this context, human cell models appear relevant in elucidating cellular and molecular impacts of neurotoxicants and facilitating prioritization of in vivo testing. The SH-SY5Y human neuroblastoma cell line (ATCC® CRL-2266™) is one of the most used cell lines in neurosciences, either undifferentiated or differentiated into neuron-like cells.
The SH-SY5Y human neuroblastoma cell line, a relevant in vitro cell ...
This review presents the characteristics of the SH-SY5Y cell line and proposes the results of a systematic review of literature on the use of this in vitro cell model for neurotoxicity research by focusing on organic environmental pollutants including pesticides, 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), flame retardants, PFASs, parabens ...
Growth Differentiation Factor 15 Protects SH-SY5Y Cells From …
2022年6月2日 · Our findings suggest that GDF15 can protect mitochondrial function and inhibit apoptosis in SH-SY5Y cells after exposure to rotenone by upregulating PGC1α via p53. These properties might comprise its anti-apoptotic effects, mediated by …
Equol Pretreatment Protection of SH-SY5Y Cells against Aβ (25–35 ...
2019年10月3日 · These data suggest that S-equol possesses a neuroprotective potential as it effectively antagonizes Aβ (25–35)-induced cell cytotoxicity and prevents cell cycle reentry in SH-SY5Y cells. The mechanism underlying S-equol neuroprotection might …
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