Serine and one-carbon metabolism in cancer - Nature
2016年9月16日 · Serine is a non-essential amino acid that can be taken up by the cell or synthesized de novo from glycolytic intermediates through the serine synthesis pathway …
Serine Protease, Enzyme Catalysis | Learn Science at Scitable - Nature
2010年8月24日 · The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and …
Phenotypic profiling of solute carriers characterizes serine …
2023年12月8日 · Serine is a vital amino acid in tumorigenesis. While cells can perform de novo serine synthesis, most transformed cells rely on serine uptake to meet their increased …
NAT10-mediated mRNA N4-acetylcytidine reprograms serine
2024年11月6日 · Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and …
Functional profiling of serine, threonine and tyrosine sites
2024年9月23日 · The use of an adenine base editor enables identification of functional serine, threonine and tyrosine residues that impact cell fitness on a genome-wide scale with possible …
Serine protease NAL1 exerts pleiotropic functions through
2023年6月22日 · A Dali (a structure comparison server) search revealed that NAL1 was a serine protease according to the structural similarity (Extended Data Fig. 1e and Supplementary …
The ins and outs of serine and glycine metabolism in cancer
2021年1月28日 · Serine and glycine synthesis (Fig. 1) consists of two processes: de novo serine synthesis from glucose and reversible interconversion of serine into glycine. De novo serine …
Variable orthogonality of serine integrase interactions within the …
2024年11月1日 · Serine integrases are phage- (or mobile element-) encoded enzymes that catalyse site-specific recombination reactions between a short DNA sequence on the phage …
Insulin-regulated serine and lipid metabolism drive peripheral ...
2023年1月25日 · Serine and glycine restriction is widely used to modulate health outcomes in mice and is relatively well-tolerated for several months 16,19,20,21,22.To model the effect of …
Design strategy for serine hydroxymethyltransferase probes based …
2019年2月20日 · Serine hydroxymethyltransferase (SHMT) is an enzyme that catalyzes the reaction that converts serine to glycine. It plays an important role in one-carbon metabolism. …
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