Serine and one-carbon metabolism in cancer - Nature
Sep 16, 2016 · Serine is a non-essential amino acid that can be taken up by the cell or synthesized de novo from glycolytic intermediates through the serine synthesis pathway (SSP). Serine is used for many ...
Serine Protease, Enzyme Catalysis | Learn Science at Scitable - Nature
Aug 24, 2010 · The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and elastase. It is transported to ...
Phenotypic profiling of solute carriers characterizes serine …
Dec 8, 2023 · Serine is a vital amino acid in tumorigenesis. While cells can perform de novo serine synthesis, most transformed cells rely on serine uptake to meet their increased biosynthetic requirements.
NAT10-mediated mRNA N4-acetylcytidine reprograms serine
Nov 6, 2024 · Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.
Functional profiling of serine, threonine and tyrosine sites
Sep 23, 2024 · The use of an adenine base editor enables identification of functional serine, threonine and tyrosine residues that impact cell fitness on a genome-wide scale with possible involvement in ...
Serine protease NAL1 exerts pleiotropic functions through
Jun 22, 2023 · A Dali (a structure comparison server) search revealed that NAL1 was a serine protease according to the structural similarity (Extended Data Fig. 1e and Supplementary Table 2).Thus, each NAL1 ...
The ins and outs of serine and glycine metabolism in cancer
Jan 28, 2021 · Serine and glycine synthesis (Fig. 1) consists of two processes: de novo serine synthesis from glucose and reversible interconversion of serine into glycine. De novo serine synthesis branches from ...
Variable orthogonality of serine integrase interactions within the …
Nov 1, 2024 · Serine integrases are phage- (or mobile element-) encoded enzymes that catalyse site-specific recombination reactions between a short DNA sequence on the phage genome (attP) and a corresponding ...
Insulin-regulated serine and lipid metabolism drive peripheral ...
Jan 25, 2023 · Serine and glycine restriction is widely used to modulate health outcomes in mice and is relatively well-tolerated for several months 16,19,20,21,22.To model the effect of systemic serine ...
Design strategy for serine hydroxymethyltransferase probes based …
Feb 20, 2019 · Serine hydroxymethyltransferase (SHMT) is an enzyme that catalyzes the reaction that converts serine to glycine. It plays an important role in one-carbon metabolism. Recently, SHMT has been shown ...
- Some results have been removed