Secreted Osteoclastogenic Factor of Activated T Cells (SOFAT) Is ...
In this study, we examined whether SOFAT is able to induce joint pain and investigated the presence of SOFAT in a Collagen-induced Arthritis (CIA) model and in human subjects. Here, we found that an intra-articular stimulation with SOFAT (1, 10, 100, or 1,000 ng/10 μl) in the knee joint significantly decreases the mechanical threshold in the ...
SOFAT as a Putative Marker of Osteoclasts in Bone Lesions
Secreted osteoclastogenic factor of activated T cells (SOFAT) is a novel activated human T-cell-secreted cytokine that induce osteoclastogenesis in a RANKL-independent manner. The aim of this study was to evaluate the immunohistochemical expression of SOFAT in intraosseous and extraosseous lesions.
In vitro evaluation of the biological effect of SOFAT on osteoblasts ...
2015年6月1日 · SOFAT is a T-cell-derived osteoclastogenic cytokine. SOFAT modulates the production of proinflammatory cytokines by osteoblastos. SOFAT did not upregulates the RANKL expression by osteoblast.
The role of secreted osteoclastogenic factor of activated T cells in ...
2022年11月1日 · They name it the secreted osteoclastogenic factor of activated T cells (SOFAT). SOFAT has been proven to play an essential role in bone remodeling, like mediating the bone resorption in rheumatoid arthritis (RA) and periodontitis.
A novel secreted osteoclastogenic factor of activated T cells (SOFAT ...
We named this cytokine secreted osteoclastogenic factor of activated T cells (SOFAT). SOFAT is derived from an unusual mRNA splice-variant coded by the threonine synthase-like 2 (THNSL2) gene homolog, a conserved gene remnant coding for threonine synthase, an enzyme that only functions in microorganisms and plants.
Secreted Osteoclastogenic Factor of Activated T Cells (SOFAT) …
2020年7月28日 · The secreted osteoclastogenic factor of activated T cells (SOFAT) is a unique cytokine and represents an alternative pathway for osteoclast activation. In this study, we examined whether SOFAT is able to induce joint pain and investigated the presence of SOFAT in a Collagen-induced Arthritis (CIA) model and in human subjects.
Secreted Osteoclastogenic Factor of Activated T Cells (SOFAT) Is ...
Secreted Osteoclastogenic Factor of Activated T Cells (SOFAT) Is Associated With Rheumatoid Arthritis and Joint Pain: Initial Evidences of a New Pathway
Secreted osteoclastogenic factor of activated T cells (SOFAT
A novel activated human T cell-secreted cytokine, referred as secreted osteoclastogenic factor of activated T cells (SOFAT), that induce osteoclastogenesis in a RANKL-independent manner was recently described. This study evaluated the role of SOFAT in …
(PDF) In vitro evaluation of the biological effect of SOFAT on ...
To better understand how SOFAT affects bone metabolism, we investigated its effect on osteoblastic cells. We demonstrate here that SOFAT did not influence MC3T3 cells viability and proliferation, evaluated by trypan blue exclusion and MTT tests, respectively.
Secreted osteoclastogenic factor of activated T cells (SOFAT), a …
2013年7月1日 · Thus, since SOFAT is a novel T cell cytokine that may activate osteoclasts independent of RANKL, the aim of this study was to evaluate the role of SOFAT in periodontal tissues and chronic periodontitis.
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