Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific ...
2023年8月26日 · In vitro, 1B7/CD3 exhibits optimal binding to both human and cynomolgus CD3 and TSLPR. Further, 1B7/CD3 was shown to induce potent T cell activation and tumor lytic …
Targeted deletion of the TSLP receptor reveals cellular ... - Nature
2020年2月17日 · Thymic stromal lymphopoietin (TSLP) is a critical upstream cytokine inducing type 2 inflammation in various diseases, including asthma and atopic dermatitis. Accumulating …
TSLP and IL-7 use two different mechanisms to regulate human CD4
2009年9月9日 · We report that resting and activated CD4 + T cells expressed high levels of IL-7 receptor a chain but very low levels of TSLP receptor (TSLPR) when compared with levels …
In vitro, 1B7/CD3 exhibits optimal binding to both human and cynomolgus CD3 and TSLPR. Further, 1B7/CD3 was shown to induce potent T cell activation and tumor lytic activity in both …
Lipopolysaccharide-Elicited TSLPR Expression Enriches a …
2017年5月1日 · TSLP activates multiple immune cell subsets expressing the TSLPR complex and plays a role in several models of disease. Although human monocytes express TSLPR and …
TSLP shapes the pathogenic responses of memory CD4 - Science
2023年9月12日 · Through bulk RNA-seq analysis of tissue CD3 + CD45 + fluorescence-activated cell sorting (FACS)–sorted T cells, we found that CRLF2 mRNA was increased in abundance …
A Novel Engineered Single-Chain Antibody Fragment for Targeting ...
2020年11月5日 · CRLF2 (also known as thymic stromal lymphopoietin receptor, TSLPR) heterodimerizes with the interleukin-7 receptor alpha (IL-7Rα) subunit to form the functional …
Activating mutation in the TSLPR gene in B-cell precursor ... - Nature
2009年11月12日 · Moreover, fluorescence-activated cell sorting (FACS) analyses of TSLPR expression at the cell surface of Ba/F3 cells showed a lower level of expression in...
TSLPR expression in human tonsils. (A) FACS analysis of TSLPR, …
We found that a subset of CD4 + CD11c + lineage (CD3, CD14, CD16, CD19, and CD56) mDCs in human tonsils (3.96%) expressed TSLPR (Fig. 5 A). The TSLPR-positive mDCs expressed …
TSLP：一种新型强效促炎介质，可激活髓样树突细胞以刺激类风湿 …
tslp 通过与 il-7 共享的白介素 (il)-7 受体-α 链 (il-7rα) 以及 tslp 受体 (tslpr) 亚基向细胞发出信号。 最近，作者证明了防止 TSLPR 信号转导强烈降低了 Th17 驱动的实验性关节炎和免疫病理学。