Ubiquitin carboxy-terminal hydrolase L1 - Wikipedia
Ubiquitin carboxy-terminal hydrolase L1 (EC 3.1.2.15, ubiquitin C-terminal hydrolase, UCH-L1) is a deubiquitinating enzyme. Neurons from rat brain tissue stained green with antibody to ubiquitin C-terminal hydrolase L1 (UCH-L1) which highlights the …
UCHL1 Gene - GeneCards | UCHL1 Protein | UCHL1 Antibody
3 天之前 · UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a Protein Coding gene. Diseases associated with UCHL1 include Spastic Paraplegia 79B, Autosomal Recessive and Parkinson Disease 5, Autosomal Dominant. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Metabolism of proteins.
Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution …
2024年8月1日 · UCH-L1 is not essential for neuronal development but it is absolutely required for the maintenance of axonal integrity and UCH-L1 dysfunction is implicated in neurodegenerative disease. Here we review the properties of UCH-L1, and how understanding its complex structure can provide new insights into its roles in neuronal function and pathology.
UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein
UCHL1/PGP 9.5 (also known as UCHL1 and PGP 9.5) was first detected as a "brain-specific protein" over 28 years ago. The protein is highly conserved and localized in neurones and neuroendocrine cells in vertebrates, forming an estimated 5-10% of cytoplasmic protein.
Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure ... - PubMed
2016年8月15日 · UCH-L1 is not essential for neuronal development but it is absolutely required for the maintenance of axonal integrity and UCH-L1 dysfunction is implicated in neurodegenerative disease. Here we review the properties of UCH-L1, and how understanding its complex structure can provide new insights into its roles in neuronal function and pathology.
泛素 C 末端水解酶 L1 (UCH-L1)：结构、分布和在脑 ... - X-MOL
UCH-L1 对神经元发育不是必需的，但它是维持轴突完整性所必需的，并且 UCH-L1 功能障碍与神经退行性疾病有关。 在这里，我们回顾了 UCH-L1 的特性， Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction.
UCHL1 ubiquitin C-terminal hydrolase L1 [ (human)]
UCH-L1 levels in cerebrospinal fluid from seizure patients show strong correlation with severity of seizures. UCH-L1 protects NOXA from proteasomal degradation by removing Lys48-linked polyubiquitin chains. UCHL1, as the major regulator of neuronal ubiquitin homeostasis, indirectly modulates the turnover of GlyT2.
The functions of UCH-L1 and its relation to ... - ScienceDirect
2007年7月1日 · Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is involved in the pathogenesis of both of these neurodegenerative diseases. Several functions of UCH-L1, other than as an ubiquitin hydrolase, have been proposed; these include acting as an ubiquitin ligase and stabilizing mono-ubiquitin.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and ...
Since its discovery as a major CNS-abundant protein 25 years ago, Ubiquitin C-terminal hydrolase-L1 (UCH-L1) has emerged as an important enzyme in regulating brain protein metabolism, by coupling to the proteasome pathway of protein degradation. Areas covered: UCH-L1 is implicated in both familial a …
A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels ...
2020年8月7日 · UCH-L1 is a deubiquitinating enzyme (DUB), highly abundant in neurons, with a sub-cellular localization dependent on its farnesylation state. Despite UCH-L1′s association with familial Parkinson's Disease (PD), the effects on mitochondrial bioenergetics and quality control remain unexplored.