Vascular Endothelial Growth Factor (VEGF) and Its Receptor …
The vascular endothelial growth factor (VEGF) and its receptor (VEGFR) have been shown to play major roles not only in physiological but also in most pathological angiogenesis, such as cancer. VEGF belongs to the PDGF supergene family characterized by 8 conserved cysteines and functions as a homodimer structure.
Impaired tumor growth and angiogenesis in mice heterozygous for
2018年10月3日 · VEGF signaling through its tyrosine kinase receptor, VEGFR2 (FLK1), is critical for tumor angiogenesis. Previous studies have identified a critical gene dosage effect of VegfA in embryonic...
Vascular Endothelial Growth Factor-D (VEGF-D): An …
2023年8月28日 · Vascular endothelial growth factors (VEGFs) are the key regulators of vasculogenesis in normal and oncological development. VEGF-A is the most studied angiogenic factor secreted by malignant tumor cells under hypoxic and inflammatory stress, which made VEGF-A a rational target for anticancer therapy.
Regulation of VEGF-A expression and VEGF-A-targeted therapy in ...
2024年4月30日 · Vascular endothelial growth factor A (VEGF-A), a highly conserved dimeric glycoprotein, is a key regulatory gene and a marker molecule of angiogenesis. The upregulation of VEGF-A facilitates the process of tumor vascularization, thereby fostering the initiation and progression of malignant neoplasms.
Biology and therapeutic targeting of vascular endothelial growth factor ...
2023年7月25日 · The consistently high expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) in human tumours and numerous studies in mouse models showing robust tumour...
Cross-species Vascular Endothelial Growth Factor (VEGF) …
Here we report the identification of novel anti-VEGF antibodies, B20 and G6, from synthetic antibody phage libraries, which block both human and murine VEGF action in vitro. Their affinity-improved variants completely inhibit three human tumor xenografts in mice of skeletal muscle, colorectal, and pancreatic origins (A673, HM-7, and HPAC).
VEGF121 and VEGF165 differentially promote vessel maturation and tumor ...
2016年4月1日 · Overexpressing either VEGF 165 or VEGF 121 in a cancer mouse model, we observed that the former decreased, whereas the latter increased tumor growth. In both clinical and experimental...
The VEGF signaling pathway in cancer: the road ahead - PMC
Mouse tumor studies have displayed the ability of VEGF-C to promote tumor angiogenesis and lymphangiogenesis in vivo and to drive tumor growth and metastatic spread [40] – [42].
The function of vascular endothelial growth factor - PMC
Vascular endothelial growth factor (VEGF) is considered the master regulator of angiogenesis during growth and development, as well as in disease states such as cancer, diabetes, and macular degeneration. This review details our current ...
Reassessing vascular endothelial growth factor (VEGF) in anti ...
2022年1月1日 · Vascular endothelial growth factor (VEGF) is a renowned pro-angiogenic factor upregulated in most cancer cells and has become a major target in most anti-angiogenic cancer therapies. Thus, this review is aimed at assessing anti-VEGF therapies and suggesting future outlooks toward improving the efficacy of anti-angiogenesis cancer therapies.