Functions and mechanisms of protein lysine butyrylation (Kbu ...
2023年11月1日 · Butyrylation (Kbu) is a new acylation process found in animals and plants. Kbu has been recently linked to the onset and progression of several diseases, such as cancer, …
Tert-Butylation - an overview | ScienceDirect Topics
Tert-butylation is a chemical process that involves the introduction of a tert-butyl group onto a molecule, typically a phenol, using alkylating agents like iso-butylene, MTBE, or tert-butyl …
Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 …
2023年7月18日 · Lysine butyrylation (Kbu) is a novel PTM that is found in histone and nonhistone proteins 8. Kbu has been identified in fungi, plants and animals 9, 10, 11, but a global …
Regioselective Aromatic Perfluoro-tert-butylation Using Perfluoro …
2022年11月22日 · We herein report the first general synthetic protocol to realize aromatic perfluoro- tert -butylation. The key to the success is the identification of PFtB phenyl sulfone …
Protein Acetylation and Butyrylation Regulate the Phenotype and ...
2018年3月9日 · During the transitional phase from acidogenesis to solventogenesis, BuP functions as phospho-donor to its central transcriptional factor Spo0A, triggering the …
Function and mechanism of histone β-hydroxybutyrylation in …
2022年9月12日 · Histone lysine β-hydroxybutyrylation (Kbhb) is a novel HPTMs identified by mass spectrometry, which regulates gene transcription in response to carbohydrate restriction …
Reaction mechanism of tert-butylation of phenol with tert-butyl …
2011年5月16日 · Tert-butylation of phenol with tert-butyl alcohol (TBA) over H-β zeolite was studied using the ONIOM approach with two proposed reaction paths: stepwise and concerted …
Fluorination Triggers Fluoroalkylation: Nucleophilic Perfluoro-
2021年10月29日 · A new perfluoro-tert-butylation protocol debuts: Consecutive triple fluorinations of 1,1-dibromo-2,2-bis(trifluoromethyl)ethylene (DBBF) generate (CF 3) 3 C − species, which …
Near quantitative synthesis of urea macrocycles enabled by bulky
2021年3月10日 · Here we report a simple, high-yielding, and robust method for constructing urea macrocycles with dynamic HUB chemistry and acid-assisted de-tert-butylation. HUMs can be …
Lysine propionylation and butyrylation are novel post-translational ...
We confirmed, by in vitro labeling and peptide mapping by mass spectrometry, that two previously known acetyltransferases, p300 and CREB-binding protein, could catalyze lysine …