Targeting claudins in cancer: diagnosis, prognosis and therapy
Claudin-6 is a strictly oncofoetal cell surface antigen whose expression is completely absent in normal human tissues but reactivated in germline tumors such as testicular, ovarian and uterine cancer .
The Claudins: From Tight Junctions to Biological Systems
Claudins are cell-cell adhesion molecules located at the tight junctions (TJs) between cells in epithelial cell sheets. The claudin family in mammals consists of 27 four-transmembrane domain proteins.
Claudin 18.2 as a novel therapeutic target - Nature
2024年3月19日 · The development and successful phase III testing of the anti-claudin 18.2 antibody zolbetuximab has provided a novel targeted therapy for the 30–40% of patients with strongly claudin 18.2 ...
Claudins and the Modulation of Tight Junction Permeability
Claudin-5, -16, and -25 appear to be unusual, due to their long NH 2 terminus and, consequently, high molecular mass. However, human mRNAs encoding these three claudins possess two start codons that potentially give rise to a short and long protein version each.
Prevalence and clinical significance of Claudin-3 expression in …
3 天之前 · Claudin-3 (CLDN3) participates in the formation of the tight-junctions (TJs) that regulate intercellular permeability. Altered CLDN3 expression has been linked to tumor progression in multiple tumor types. Despite its widespread expression in normal epithelial cells, CLDN3 is considered an attractive drug target candidate, since it may be more accessible in cancer cells …
Structure and function of claudins - ScienceDirect
2008年3月1日 · Transfected claudin-19 increased transepithelial resistance and decreased cation permeability [48]. Taken together, a tightness function can be demonstrated for claudin-1, -5, -11, and -14. For claudin-3, -4, -8, and -19, a tightening potential is indicated.
Claudins: Control of Barrier Function and Regulation in Response …
Claudins are a family of nearly two dozen transmembrane proteins that are a key part of the tight junction barrier that regulates solute movement across polarized epithelia. Claudin family members interact with each other, as well as with other ...
The Claudins: From Tight Junctions to Biological Systems
2019年2月1日 · The claudin protein family, which has 27 members in mammals, consists of tight junction (TJ) proteins that are indispensable for the paracellular barrier in vertebrate epithelial cell sheets.
Claudin 18.2 as a novel therapeutic target I Nakayama 1,5, C Q 2,5, Y C 2, Y Nakamur ...
High Expression of CLDN 18.2 is Associated with Poor Disease …
2024年4月29日 · Anti-claudin (CLDN) 18.2 therapy has been proven to be effective in treating advanced gastric cancer with negative human epidermal growth factor receptor 2 (HER-2). This study purposed to investigate the relationship of CLDN 18.2 expression with prognosis of HER-2-positive gastric cancer patients.
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