ERK signalling: a master regulator of cell behaviour, life and fate
2020年6月23日 · The core RAS–ERK pathway is typically initiated at the plasma membrane, where guanosine triphosphate (GTP)-loaded RAS directly contacts the RAF kinases and induces catalytic activity through a...
MAPK/ERK pathway - Wikipedia
The EGFR-ERK/MAPK (epidermal growth factor receptor extracellular-regulated kinase/mitogen-activated protein kinase) pathway stimulated by EGF is critical for cellular proliferation, but the temporal separation between signal and response obscures the signal-response relationship in previous research.In 2013, Albeck et al. [9] provided key ...
A comprehensive pathway map of epidermal growth factor …
The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best-investigated signaling systems, both experimentally and computationally, and several computational models ...
Epidermal Growth Factor Receptor (EGFR) Pathway, Yes …
The epidermal growth factor receptor (EGFR) pathway is a well-studied oncogenic pathway in human non-small cell lung cancer (NSCLC). A subset of advanced NSCLC patients (15–55%) have EGFR-driven mutations and benefit from treatment with ...
Feedback regulation of EGFR signalling: decision making by early …
2011年1月21日 · Using PC-12 cells to validate mathematical modelling, it was shown that stimulation of ERK by NGF activates the upstream kinase RAF to cause positive feedback, whereas ERK activation by EGF ...
Computational modelling of cancerous mutations in the EGFR/ERK ...
2009年10月5日 · We have generated a new model of the EGFR activated ERK pathway, which was verified by our own experimental data. We then altered our model to represent various cancerous situations such as Ras, B-Raf and EGFR mutations, as well as EGFR overexpression.
HPIP is an essential scaffolding protein running through the EGFR …
2023年6月9日 · We demonstrated that HPIP is essential for formation of EGFR-RAS-ERK signaling complexes, activation of the EGFR-RAS-ERK pathway and EGFR-RAS-ERK signaling–mediated promotion of aerobic glycolysis, as well as cancer cell proliferation in vitro and tumor growth in vivo.
Epidermal Growth Factor (EGF) Receptor-dependent ERK …
In COS-7 cells, α2A-adrenergic receptors (ARs) stimulate ERK phosphorylation via two distinct pathways, a transactivation pathway that involves the release of HB-EGF and the EGFR and an alternate pathway that is independent of both HB-EGF and the EGFR.
EGFR-RAS-MAPK signaling is confined to the plasma membrane …
2021年9月13日 · We propose that a small pool of surface EGFRs sustain signaling within the RAS-ERK1/2 pathway and that RAS activation persists in TERCs, whereas endosomal EGFR does not significantly contribute to ERK1/2 activity.
An image-based RNAi screen identifies the EGFR signaling pathway …
2 天之前 · Combining functional approaches, phospho-mapping and generation of phospho-variants, we further showed that EGFR signaling inhibits Imp-positive RNP granule assembly through activation of the MAPK-ERK pathway and downstream phosphorylation of Imp at …