Single-drug versus combination antimicrobial therapy in critically …
2024年1月3日 · Key messages In this study including 391 critically ill patients with nosocomial pneumonia due to Gram-negative pathogens, combination therapy was not associated with a reduced hazard of death at Day 28 or a greater likelihood of clinical cure at Day 14. No over-risk of AKI was observed in patients receiving combination therapy. Background The benefits and harms of combination antimicrobial ...
Association between combination antibiotic therapy as opposed …
2023年5月30日 · Background The optimal treatment duration and the nature of regimen of antibiotics (monotherapy or combination therapy) for Pseudomonas aeruginosa ventilator‑associated pneumonia (PA-VAP) remain debated. The aim of this study was to evaluate whether a combination antibiotic therapy is superior to a monotherapy in patients with PA-VAP in terms of reduction in recurrence and death, based on ...
Antiepileptic drugs in critically ill patients - Critical Care
2018年6月7日 · Background The incidence of seizures in intensive care units ranges from 3.3% to 34%. It is therefore often necessary to initiate or continue anticonvulsant drugs in this setting. When a new anticonvulsant is initiated, drug factors, such as onset of action and side effects, and patient factors, such as age, renal, and hepatic function, should be taken into account. It is important to note ...
Combination of extracorporeal membrane oxygenation and …
2014年12月8日 · Introduction Extracorporeal membrane oxygenation (ECMO) is used in critically ill patients presenting acute cardiac and/or pulmonary dysfunctions, who are at high risk of developing acute kidney injury and fluid overload. Continuous renal replacement therapy (CRRT) is commonly used in intensive care units (ICU) to provide renal replacement and fluid management. We conducted a review to assess ...
Choosing the right combination therapy in severe community …
2006年1月24日 · Recent studies have suggested that combination antibiotic therapy is preferable to monotherapy for severe community-acquired pneumonia (CAP). In this issue Mortensen and colleagues present retrospective data suggesting that combination therapy with a cephalosporin and a fluoroquinolone is inferior to combination therapy with a cephalosporin and a macrolide. Several mechanisms exist by which ...
Clinical review: Critical illness polyneuropathy and myopathy
2008年11月25日 · Many reports have found CIM to occur in patients treated with a combination of CSs and neuromuscular blocking agents (NMBAs). The myopathy that occurs in these patients mostly treated for severe asthma, chronic obstructive pulmonary disease, solid organ transplantation, leukemia, or lymphoma is most commonly a thick-filament myopathy.
Antibiotic prescription patterns in the empiric therapy of severe ...
2012年11月18日 · Introduction Although early institution of adequate antimicrobial therapy is lifesaving in sepsis patients, optimal antimicrobial strategy has not been established. Moreover, the benefit of combination therapy over monotherapy remains to be determined. Our aims are to describe patterns of empiric antimicrobial therapy in severe sepsis, assessing the impact of combination therapy, including ...
Monotherapy or combination antibiotic therapy in the treatment …
2023年9月22日 · Second, several studies have also investigated the efficacy of combination and monotherapy in PA-VAP. For instance, in a previous multicenter cohort study [] including 183 PA-VAP patients, Dr. Montero et al. also reported that the overall mortality was comparable between the monotherapy and combination therapy groups, supporting the current study's findings.
Combination of serum and peritoneal 1.3-beta- - BioMed Central
2023年11月30日 · Background Intra-abdominal candidiasis (IAC) is difficult to predict in critically ill patients with intra-abdominal infection, leading to the overuse of antifungal treatments. Serum and peritoneal 1.3-beta-d-glucan (sBDG and pBDG) have been proposed to confirm or invalidate the diagnosis of IAC, but clinical studies have reported inconsistent results, notably because of heterogeneous ...
Combination of thrombin-antithrombin complex, plasminogen …
2014年1月13日 · Introduction Current criteria for early diagnosis of coagulopathy in sepsis are limited. We postulated that coagulopathy is already complicated with sepsis in the initial phase, and severe coagulopathy or disseminated intravascular coagulation (DIC) becomes overt after progressive consumption of platelet and coagulation factors. To determine early diagnostic markers for severe coagulopathy, we ...