Metallothionein: A Comprehensive Review of Its Classification ...
Metallothionein is a cysteine-rich protein with a high metal content that is widely found in nature. In addition to heavy metal detoxification, metallothionein is well known as a potent antioxidant.
Metallothionein - an overview | ScienceDirect Topics
Metallothioneins are small proteins that bind to heavy metals such as cadmium, zinc, and copper. They are rich in sulfhydryl groups and can be found in various tissues, including the liver, kidney, and intestine.
Metallothionein: An overview - PMC - PubMed Central (PMC)
Metallothioneins (MTs) were discovered in 1957 by Margoshes and Vallee and identified as low-molecular weight sulphydryl rich proteins. Due to their high metal content and unusual bioinorganic structure, they are distinguished as metalloproteins.
Metallothioneins: Emerging Modulators in Immunity and Infection
Metallothioneins (MTs) are a family of metal-binding proteins virtually expressed in all organisms including prokaryotes, lower eukaryotes, invertebrates and mammals. These proteins regulate homeostasis of zinc (Zn) and copper (Cu), mitigate heavy metal poisoning, and alleviate superoxide stress.
A Review of Metallothionein Isoforms and their Role in …
2011年5月20日 · Strong evidence exists that MT modulates complex diseases and the immune system in the body but the primary function of MT still remains unknown. This review's main objective is to explore the capability to specifically manipulate MT levels in cells and in animals to provide answers regarding how MT could impact those complex disease scenarios.
Metallothioneins, Unconventional Proteins from Unconventional …
2014年4月22日 · Metallothioneins (MTs) are ubiquitous low molecular weight cysteine-rich proteins characterized by high affinity for d10 electron configuration metals, including essential (Zn and Cu) and non-essential (Cd and Hg) trace elements.
Metallothionein - an overview | ScienceDirect Topics
Metallothionein is a stress-inducible protein with free radical scavenging capacity. Metallothionein is one of few genes known to increase mouse lifespan if overexpressed. Emerging data highlight a protective role of metallothionein against obesity. Metallothionein is modulated by caloric restriction and insulin-like signals. Future work should ...
Metallothioneins, a Diverse Protein Family - PMC - National Center …
Metallothioneins and phytochelatins are Cys-rich metal chelators that represent the two principal groups of metal-binding proteins found across most taxonomic groups. Although MTs were originally identified in animals by their ability to protect against cadmium toxicity, their role in plant systems is still being determined.
Metallothionein - an overview | ScienceDirect Topics
Metallothionein (MT) is a low molecular mass protein of approximately 6500 Dalton with a high content of SH-groups from cysteine. Two distinct metal binding domains, the α- and β-clusters have been characterized in MT and are formed of the 61 amino acids in human MT.
Metallothionein: A Comprehensive Review of Its Classification
2024年7月9日 · Metallothionein is a cysteine-rich protein with a high metal content that is widely found in nature. In addition to heavy metal detoxification, metallothionein is well known as a potent antioxidant.
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